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Because Proviron is not C-17 alpha alkylated (it is instead methylated on its first carbon), research has shown that it is not known to produce hepatotoxic effects, and liver problems are extremely unlikely with this compound. Proviron’s side effects do indeed include negative impacts on the cardiovascular system, however. Studies have shown that 100mg of Proviron daily for 6 months has shown very significant negative effects on cholesterol values, both increasing the bad (LDL) cholesterol and decreasing the good (HDL) cholesterol by 65% and 35% respectively. It is also likely that Proviron may have a suppressive effect on endogenous natural Testosterone production (though this is considered to be very weak). Nevertheless, studies have demonstrated that 150mg or less per day of Proviron that no significant suppression of Testosterone results. In those same studies, higher dosages (300mg or higher per day) resulted in significant suppression of Testosterone levels. 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