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In a fertility and early embryonic development toxicity study in female rats, oral administration of letrozole starting 2 weeks before mating until pregnancy day 6 resulted in an increase in pre-implantation loss at doses ? 0. In an embryo-fetal developmental toxicity study in rats, daily administration of oral letrozole during the period of organogenesis at doses 0., best steroid muscle building. Letrozole was teratogenic to rats at a dose of 0. In the embryo-fetal development toxicity study in rabbits, daily administration of oral letrozole during the period of organogenesis at doses ? 0. Fetal anomalies included incomplete ossification of the skull, sternebrae, and fore- and hind legs. It is not known if letrozole is present in human milk. There are no data on the effects of letrozole on the breastfed infant or milk production. Exposure of lactating rats to letrozole was associated with impaired reproductive performance of the male offspring (see Data). 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