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Clinical monitoring is recommended when co-administering boosted PREZISTA with these sedatives/hypnotics and a lower dose of the sedatives/hypnotics should be considered. If parenteral midazolam is co-administered with boosted PREZISTA, it should be done in an intensive care unit (ICU) or similar setting, which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation. Dose adjustment for midazolam should be considered, especially if more than a single dose of midazolam is administered. Boosted PREZISTA with triazolam or oral midazolam is contraindicated (see section 4. TREATMENT FOR PREMATURE EJACULATION. Co-administration of boosted PREZISTA with dapoxetine is contraindicated. Monitor for fesoterodine or solifenacin adverse reactions, dose reduction of fesoterodine or solifenacin may be necessary. According to current treatment guidelines, dual therapy with protease inhibitors is generally not recommended. As a general rule, when deciding to use antiretroviral agents for the treatment of HIV infection in pregnant women and consequently for reducing the risk of HIV vertical transmission to the newborn, the animal data as well as the clinical experience in pregnant women should be taken into account. There are no adequate and well controlled studies on pregnancy outcome with darunavir in pregnant women. Studies in animals do not indicate direct harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5. PREZISTA co-administered with low dose ritonavir should be used during pregnancy only if the potential benefit justifies the potential risk. Treatment with darunavir/cobicistat 800/150 mg during pregnancy results in low darunavir exposure (see section 5. Therapy with PREZISTA/cobicistat should not be initiated during pregnancy, and women who become pregnant during therapy with PREZISTA/cobicistat should be switched to an alternative regimen (see sections 4. It is not known whether darunavir is excreted in human milk. Studies in rats have demonstrated that darunavir is excreted in milk and at high levels (1,000 mg/kg/day) resulted in toxicity. Because of both the potential for HIV transmission and the potential for adverse reactions in breast-fed infants, mothers should be instructed not to breast-feed under any circumstances if they are receiving PREZISTA. No human data on the effect of darunavir on fertility are available. There was no effect on mating or fertility with darunavir treatment in rats (see section 5. PREZISTA in combination with cobicistat or ritonavir has no or negligible influence on the ability to drive and use machines. However, dizziness has been reported in some patients during treatment with regimens containing PREZISTA co-administered with cobicistat or low dose ritonavir and should be borne in mind when considering a patient’s ability to drive or operate machinery (see section 4. Summary of the safety profile, ultima tren e 200 mg injectable steroids trenbolone enanthate. During the clinical development program (N=2,613 treatment-experienced subjects who initiated therapy with PREZISTA/ritonavir 600/100 mg twice daily), 51. The total mean treatment duration for subjects was 95. The most frequent adverse reactions reported in clinical trials and as spontaneous reports are diarrhoea, nausea, rash, headache and vomiting.
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