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Signs of Sleep Apnea Obesity and COVID Risks Cataracts Easy to Treat Novavax’s COVID Vaccine Teasing to Eating Disorders More Health News ‘ Trending on MedicineNet. Squamous Cell Carcinoma (Skin Cancer) Hantavirus Pulmonary Syndrome (HPS) Heat Stroke Symptoms Blood Pressure Chart Sunburn Relief. What Are Biologics and Biosimilars? What are the differences between the types of systemic corticosteroids? Corticosteroids differ in their relative amount of anti-inflammatory and mineralocorticoid potency and they are used according to these effects. Among the systemic (oral and injectable) corticosteroids, fludrocortisone (Florinef) has the most significant mineralocorticoid (salt retaining) actions and is best used for this effect despite it’s strong anti-inflammatory action. Other systemically available corticosteroids have mostly glucocorticoid effects, and are used for their anti-inflammatory activities. 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