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Fat solubility: Anabolic steroids by nature are lipids (fats), though they are not the traditional chemical characteristic of a hydrocarbon chainat room temperature. These lipids are more stable than oils, which is why they are often used as ointments for skin or as liposomes for tissue engineering.
Fruit: As part of their chemical structure and physical arrangement, steroids are generally unsaturated fatty solids. Their solubility is generally dependent not only on the presence of the molecule that is being dissolved, but on its pH as well. Some species are more stable than others in water. This is a common aspect of the synthesis of drugs like meldonium and methylfolate.
Lipase: A hormone produced by the liver that assists the breakdown of lipids into energy by an enzyme, lipoprotein lipase. Lipids are not always dissolved properly in a water-based solution; a higher pH is not always optimal for drug manufacturing with lipoprotein lipase.
The final factor that determines the stability and solubility of the active agent is the presence of an inhibitor. The effect of an inhibiting agents on the activity of the enzyme being used to break down the steroid molecule is dependent on the number, location and type of the inhibitor present. Examples include, but are not limited to, sulfates, ketones, esters and alkoxyls. Most compounds found in any drug product have one or more inhibitors.
For an overview of the most commonly used inhibitors see the Table of Drug Intermediates in Table of Metabolite Compounds
Table 3: Drug Intermediates
Table 3 shows the most well researched inhibitors of the steroid hormone: meldonium, methylfolate and hydantoin.
Table 3: Drug Intermediates
The most commonly used drugs to lower the body’s testosterone levels are oral contraceptives , and testosterone injections. These substances are not as specific as steroids and have multiple effects ranging from reducing bone density to boosting the immune system, thus enhancing the effectiveness of other drugs.
, and testosterone injections. These substances are not as specific as steroids and have multiple effects ranging from reducing bone density to boosting the immune system, thus enhancing the effectiveness of other drugs. Oral contraceptives are usually used in combination with other forms of testosterone replacement therapy : progestins (such as levonorgestrel) and testosterone (such as testosterone propionate).
: progestins (such as levonorgestrel) and testosterone (such as testosterone propionate). The use of progesterone has a variety of additional effects.
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