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Athletes who use oral anabolic steroids nearly always show depressed HDL levels as the buildup of 17-alpha alkylated oral anabolic steroids in the liver leads to a type of toxic or chemical hepatitis. The liver converts a body compound into toxic substances, including estrogens. This is especially critical for the female athlete. Anabolic steroids increase the amount of the body’s estrogen receptors, which can make the body more vulnerable to the effects on the developing fetus.[3] In particular, anabolic steroids can affect a developing female fetus, since they increase the levels of estradiol and progesterone.[1,6] These actions on the developing fetus create “fetal toxicity.”
In 2008, a team of researchers published the results of their study which measured blood levels of estrogen as well as progesterone and tested their metabolism and potential adverse effects on the developing infant. They discovered a high level of 17-alpha-hydroxy estradiol (17-OHE) in blood and, as such, they stated: “This is a highly significant finding, which warrants further attention.”[7]
In the research, the researchers did not differentiate between oral and injected anabolic steroids, in order to ensure that the findings of the report are applicable to the entire population and they concluded that: “Anabolic-to-androgenic steroid metabolism and human fetal toxicity in women are distinct and should be recognized”.[7] As a result, the authors of the 2008 report advised women to avoid the use of anabolic steroids, and emphasized that a woman must be diagnosed with anabolic-to-androgenic steroid toxic syndrome before using any type of anabolic steroid.[8]
The research team was led by Dr. Eileen N. Wigderson, and was assisted by Dr. Jennifer N. Bittner, and Dr. Daniel B. Kiek, Department of Public Health, Purdue University.[9]
Conclusion
Although the study had limitations, it has gained a large amount of attention by the sports medicine community and has contributed to a growing body of knowledge for understanding and treating anabolic-to-androgenic steroid toxicity. Because anabolic-to-androgenic steroids are often prescribed by many female athletes, this is a very important issue. The use of anabolic-to-androgenic steroid (AAS) has been linked to a number of adverse effects, including cancer, birth defects, brain damage, and cognitive impairment.
Furthermore, as of December 2008, it was recognized that there are “serious adverse events” in regards to pregnant and breastfeeding women that include hypoglycemic changes, nausea, vomiting, and a history of maternal depression and suicidal thoughts
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