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ARIMIDEX ‘ no ha sido investigado en pacientes con insuficiencia hepatica o renal severa. El potencial riesgo/beneficio para tales pacientes debe ser cuidadosamente considerado antes de la administracion de ARIMIDEX ‘. Como ARIMIDEX ‘ disminuye los niveles de estrogenos circulantes, puede ocasionar una reduccion en la densidad mineral osea teniendo como probable consecuencia un incremento en el riesgo de fracturas. Este posible incremento de riesgo debe manejarse de acuerdo a las guias de tratamiento para la salud osea en mujeres postmenopausicas. Efectos en la habilidad para conducir u operar maquinaria: Es poco factible que ARIMIDEX ‘ altere la capacidad para conducir un vehiculo u operar maquinaria. Sin embargo, astenia y somnolencia han sido asociadas al uso de ARIMIDEX ‘ , por lo que se debe tener precaucion al conducir un vehiculo u operar maquinaria mientras tales sintomas persistan. DOSIS Y VIA DE ADMINISTRACION: Adultos (incluyendo pacientes de edad avanzada): Una tableta de 1 mg al dia por via oral. Ninos: No se recomienda usar en ninos, ya que su eficacia no ha sido establecida (vease Farmacocinetica y farmacodinamia). Insuficiencia renal: No se recomienda modificar la dosis. Insuficiencia hepatica: No se recomienda modificar la dosis. MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACION O INGESTA ACCIDENTAL: Existe experiencia clinica limitada en relacion a sobredosis de ARIMIDEX ‘, bold 300 pharma. No hay reportes de que algun paciente haya tomado una dosis que exceda los 60 mg. No se ha observado toxicidad ni tampoco se ha visto ningun efecto clinico relevante. Se observo toxicidad aguda en animales con una dosis mayor de 45 mg/kg (equivalente a 2. Se han realizado estudios clinicos con dosis unicas de hasta 60 mg en voluntarios sanos hombres y hasta 10 mg diarios en mujeres postmenopausicas con cancer de mama avanzado; ambas dosis resultaron bien toleradas. No se ha establecido una dosis unica de ARIMIDEX ‘ que produzca sintomas que pongan en peligro la vida. No existe un antidoto especifico para la sobredosis y su tratamiento debe ser sintomatico. Durante el manejo de una sobredosis debe considerarse la posibilidad de que multiples agentes hayan sido ingeridos. El vomito puede inducirse si el paciente se encuentra consciente. La dialisis puede ser util debido a que ARIMIDEX ‘ no se une fuertemente a proteinas. Cuidados generales, incluyendo la vigilancia frecuente de los signos vitales y la observacion cercana del paciente, son medidas indicadas. Caja con 14 tabletas con 1 mg en envase de burbuja. Caja con 28 tabletas con 1 mg en envase de burbuja. RECOMENDACIONES SOBRE ALMACENAMIENTO: Conservese a temperatura ambiente a no mas de 30’C y en lugar seco. LEYENDAS DE PROTECCION: Su venta requiere receta medica.
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