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As Testosterone Cypionate was the American response to the international product Testosterone Enanthate, many American bodybuilders and athletes throughout the 1960s, 70s, and 80s preferred the use of Testosterone Cypionate over the Enanthate variant for no reason other than the support of an American product, very much akin to an issue of pride (once again, the Cypionate and Enanthate variants of Testosterone are both almost 100% identical and there is no practical reason to prefer one compound over the other). As previously mentioned, Testosterone Cypionate is simply Testosterone with the Cypionate ester bound to the Testosterone chemical structure. Specifically ‘Cypionate’ is Cypionic acid, but once bound to Testosterone it is properly referred to in chemistry as an ester bond (or ester linkage). Cypionic acid is chemically bound to the 17-beta hydroxyl group on the Testosterone structure. Esterified anabolic hold a greater degree of solubility in fats, and therefore release slower from the injection site in comparison to un-esterified Testosterone ‘ however, this is not the main reason as to why esters extend the release rate and half-life of the given anabolic steroid it is attached to. The primary reason for the augmentation of its half-life and release rate is due to the fact that when Testosterone Cypionate enters the bloodstream, enzymes will bind to the Testosterone Cypionate molecule and break the bond between the ester and the hormone, which takes a varying amount of time depending on the size of the ester in question. This is why larger esters such as Cypionate, Enanthate, Decanoate, and so forth all possess longer half-lives than the smaller shorter esters such as Propionate, Phenylpropionate, Acetate, etc. Therefore, the end result is that the ester is removed from the hormone via enzymes, and what is left over following this chemical interaction is pure Testosterone that is free to do its work in the body. This process of enzymes cleaving off the ester from the Testosterone molecule is what is ultimately responsible for the slower release rates. Pure Testosterone alone with no ester bonded to it possesses a half-life of approximately 2 ‘ 4 hours. When the Cypionate ester is attached to it, creating Testosterone Cypionate, the half-life of Testosterone is now extended to 12 days, which results in a slower release and activity of the hormone. 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