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In February of 2020 a review study with the title ‘Medical Reversals in Family Practice: A Review,’ ( 5 ) published in the journal Current Therapeutic Research, Clinical and Experimental offered these points: Although surgery and cortisone are common, randomized trials have failed to produce evidence for their effectiveness. Although these practices are common, randomized trials have failed to produce evidence for their effectiveness. Further, patients assigned to the triamcinolone treatment had a greater loss in cartilage thickness. Moving forward on research surrounding knee osteoarthritis: Cortisone can make bone on bone worse by thinning out the meniscus, buy nandro 100 mg injectable steroids nandrolone propionate. But one injection appears okay. One of the reasons that you are considering a knee replacement or are thinking about getting a cortisone injection is because you have been told you have a bone on bone knee. So the idea that cortisone may make this worse by thinning out your meniscus is concerning doctors. In August of 2020 in the journal Scientific Reports ( 6 ) doctors expressed concerns about damaging the meniscus tissue with cortisone injections. It should be noted that this research’s main findings were that it was okay to get one cortisone injection. For many people, one injection would be considered safe. Here are the learning points of that research: Although intra-articular corticosteroid injections are commonly used for the treatment of knee osteoarthritis, there is controversy regarding possible side-effects on the knee joint structure. In this study, the effects of intra-articular corticosteroid injections on worsening the knee structure and creating greater pain were examined. Findings: No significant effect of the intra-articular corticosteroid injections were found on the rate of cartilage loss nor on any other knee structural changes or patient-reported pain scores. In conclusion, a single intra-articular corticosteroid injection for the treatment of osteoarthritis-related knee pain was shown to be safe with no negative impact on structural changes, but there was a transient meniscal thickness reduction, a phenomenon for which the clinical relevance is at present unknown. The cortisone debate goes on. A December 2020 ( 7 ) study published in the medical journal Rheumatology gives this overview assessment of the debate surrounding the use of cortisone for a bone on bone knee. Here are the summary learning points: ‘Existing data indicate that intra-articular corticosteroids in knee osteoarthritis provide short-term pain relief and functional improvement which may last from one to several weeks. At present, synovitis (inflammation) is the most important predictor of treatment response, and also a target for anti-inflammatory treatment for intra-articular corticosteroids. 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